Driving Forces for Transmembrane α-Helix Oligomerization
نویسندگان
چکیده
منابع مشابه
Robust driving forces for transmembrane helix packing.
The packing structures of transmembrane helices are traditionally attributed to patterns in residues along the contact surface. In this view, besides keeping the helices confined in the membrane, the bilayer has only a minor effect on the helices structure. Here, we use two different approaches to show that the lipid environment has a crucial effect in determining the cross-angle distribution o...
متن کاملSupporting Material: Robust Driving Forces for Transmembrane Helix Packing
• We refine the database to include only proteins with TM helices. This includes alpha-helical polytopic and alpha-helical bitopic OPM classes as of September 2011 (357 TM proteins, 261 unique). The full list of MPs is available in Table S2. • We extract the structure of each such protein from the database. • We extract other supporting information on the protein such as the hydrophobic thickne...
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Changes in pH can alter the structure and activity of proteins and may be used by the cell to control molecular function. This coupling can also be used in non-native applications through the design of pH-sensitive biomolecules. For example, the pH (low) insertion peptide (pHLIP) can spontaneously insert into a lipid bilayer when the pH decreases. We have previously shown that the α-helicity an...
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In the Rhodobacter (Rba.) species of photosynthetic purple bacteria, a single transmembrane α-helix, PufX, is found within the core complex, an essential photosynthetic macromolecular assembly that performs the absorption and the initial processing of light energy. Despite its structural simplicity, many unresolved questions surround PufX, the most important of which is its location within the ...
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Methods that predict membrane helices have become increasingly useful in the context of analyzing entire proteomes, as well as in everyday sequence analysis. Here, we analyzed 27 advanced and simple methods in detail. To resolve contradictions in previous works and to reevaluate transmembrane helix prediction algorithms, we introduced an analysis that distinguished between performance on redund...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2010
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.03.071